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Synergy Marketing

Menopause & Aging It's about restoring vitality & balance!

Enhance your equinimity

  All  supplement hormone products are bio-Identical extracted from plants, and developed by a Ph.D. chemist as a proprietary product of Specialty Formulations & Manufacturing in Phoenix Arizona.


 Karma-Flo hormones are  molecularly bio-identical to that which the body makes naturally.Topical hormone creams are absorbed directly into the circulation  thus bypassing the liver and therefore allowing for much lower doses  than oral preparations.


DHEA Topical Cream

Dehydroepiandrosterone (DHEA) is a hormone secreted by the  adrenal gland. It is a parent hormone which can be converted in the body  to either testosterone or estrogen depending on the body’s needs.  Natural DHEA levels peak in early adulthood and then slowly decrease as  you age.

Topical hormone creams are absorbed directly into the  circulation thus bypassing the liver and therefore allowing for much  lower doses than oral preparations.

Standard provides 15mg bio-identical DHEA USP per pump. 


Bi-estroderm Creme

 Karma Flo Bi-Estroderm Cream is a  combination of two bioidentical estrogens in a balanced 80/20 ratio of  estriol/estradiol. Topical hormone cream is absorbed directly into the  circulation thus bypassing the liver and therefore allowing for much  lower doses than oral preparations.

Standard Provides 1mg Estriol (E3) and 0.25mg of Estradiol (E2) per pump.

4 fl oz container dispenses 80 pumps

2 fl oz container  dispenses 40 pumps  

Directions:  Apply one full pump 1-2 times per day or as  recommended by your health care practitioner. Apply to chest, abdomen,  inner arms, or thighs, rotating sites each time.


Estriol Cream

The reduction of hormone levels during perimenopause and menopause  create numerous changes in women’s bodies. Effects can be drastic and  include irregular periods, hot flashes, night sweats, thinning hair,  vaginal dryness, painful intercourse, irritability, mood swings, mental  fog, dry skin, decreased metabolic rate causing weight gain, loss of  bone density.

Estriol is the weakest form of estrogen. It is also the safest  because it protects against the adverse effects of the stronger  estrogens, estradiol and estrone. Studies suggest that it can help  reduce a variety of symptoms associated with perimenopause and  menopause.

Benefits of estriol include

  • Restore vaginal lubrication and elasticity
  • Reduce or eliminate hot flashes and night sweats.
  • Wipe out fatigue, mental fogginess, and menopause-related mood swings and depression.
  • Diminish menopause-related weight gain and redistribution.
  • Prevent post-menopausal bone loss

 Topical hormone creams are absorbed directly into the circulation  thus bypassing the liver and therefore allowing for much lower doses  than oral preparations.

Standard – 0.75 mg estriol/1.5ml meter dosed pump


Progesterone

Progesterone helps to regulate the menstrual cycle, but its main job  is to get the uterus ready for pregnancy. Levels naturally begins to  fall around the age of 35. Progesterone is the first of the three sex  hormones (progesterone, estrogen and testosterone) to decline resulting  in an imbalance of estrogen and progesterone known as of estrogen  dominance.  Symptoms of low progesterone include breast tenderness,  headaches, fatigue, lack of libido, depression, anxiety, moodiness,  abnormal uterine bleeding, and difficulty conceiving.

Benefits of progesterone include

  • Counterbalances and opposes effects of estrogen
  • Relief for menopause and PMS symptoms
  • Relief for fibrocystic breast pain
  • Alternative to traditional synthetic hormone therapy
  • Stimulates production of new bone cells

 Topical hormone creams are absorbed directly into the circulation  thus bypassing the liver and therefore allowing for much lower doses  than oral preparations.

Standard – 20 mg progesterone/1.5ml meter dosed pump


 Progesterone offers various benefits, including support for reproductive health, mood regulation, and potentially improved sleep and bone health. It plays a vital role in maintaining a healthy menstrual cycle, supporting pregnancy, and balancing hormones. Progesterone  also contributes to brain health, potentially aiding in mood  stabilization, anxiety reduction, and even helping with certain  cognitive functions 

    

Pregnenelone

Pregnenolone is a precursor to many of the body’s hormones. As we age  its production declines just as the hormones DHEA, progesterone,  estrogen and testosterone and decline. Supplementing with pregnenolone  can serve to boost production of these hormones. 

 Pregnenolone,  a naturally occurring hormone in the body, is a precursor to many other  hormones, including DHEA, progesterone, estrogen, testosterone, and  cortisol. It is also synthesized in the brain and nervous system,  where it acts as a neurosteroid and can modulate various brain  functions. Here are some potential benefits associated with pregnenolone:

  • Cognitive Enhancement:
  • Mood Regulation and Stress Resilience:
    • It  can increase allopregnanolone, which activates GABA receptors, leading  to calming effects and potentially reducing symptoms of anxiety and  depression.
    • Low levels of pregnenolone have been linked to depression and anxiety.
  • Adrenal Health and Energy Support:
    • It  may help support cortisol production and rebuild adrenal reserves,  potentially aiding individuals experiencing adrenal fatigue or chronic  burnout.
    • It may enhance daytime energy levels and metabolic vitality.
    • Pregnenolone has been studied for its potential to combat fatigue and boost energy.
  • Sleep Improvement:
    • Studies  suggest pregnenolone and its derivative allopregnanolone can stimulate  deep sleep, which may be beneficial for individuals with sleep  disturbances or insomnia.
  • Other Potential Benefits:
    • Pregnenolone has anti-inflammatory properties.
    • It may help maintain immune balance.
    • It's used for addressing menopausal and PMS symptoms, and endometriosis.
    • It may be used for certain skin conditions like psoriasis and scleroderma

Made in the USA. Karma Flo products are manufactured  under the strict guidelines of the U.S. Food and Drug Administration’s  Good Manufacturing Practices (GMP). Karma Flo products have not been evaluated by the FDA and are not intended to diagnose, treat, or prevent any disease.  

  • Fragrance Free
  • Paraben Free
  • No Animal Testing
  • No Animal Products


Inactive ingredients of all creme applications: Purified water, Aloe Barbadensis Gel, Glycerin,  Isopropyl Palmitate, Stearic Acid, Caprylic/Capric Triglycerides,  Glyceryl Stearate, Emulsifying Wax NF,  Phenoxyethanol,  Sodium Bicarbonate, Potassium Sorbate, Allantoin, Lecithin, Oenothera  Biennis (Evening Primrose), Tocopherol.   

  • 4 fl oz container dispenses 80 pumps
  •  2 fl oz container  dispenses 40 pumps         

Directions: 

Use Only As Directed or as recommended by your health care professional.


 Apply to chest, abdomen, inner arms or thighs, rotating sites each time.


Menstruating Women  Apply a full pump once or twice a day as needed,  starting on the 12th day after the first day of menstrual flow thru the  28th day.


Menopausal or Post-Menopausal Women: Apply a full pump once or twice a day for a maximum of 21 consecutive days/month. 


FDA Topical Dosage Considerations:


 The average  amount of estrogen in a 25-year-old woman varies throughout her  menstrual cycle, but generally falls within the range of 30 to 400 pg/mL (picograms per milliliter). This is considered within the normal range for pre-menopausal women 


The pump dispenser is metered to deliver the exact amount of hormones for each pump. Therefore, the FDA requirements are in compliance to obviate the requirement for a prescription, and the product qualifies to be sold cover-the-counter.


What is HRT?

Naturally derived  bio-identical HRT products for menopause are not typically sold  over-the-counter (OTC) without a prescription because they they are most often administered by ingestion, or injection.  However our affiliate company is also private labeling our proprietary product to other vendors-- which are requiring prescriptions, and selling the product  at a 200% to 300% higher price than OTC.


Although the  FDA regulates compounded bio-identical hormone replacement therapy (B-HRT) that is administered topically,  the FDA has already established a "Monograph", which would not only include the chemical, but also the dosages and manner of application. Topical application at a pre-measured dosage, is exempt  from FDA compliance with the necessity of performing  a  "Time and Extent" (T&E) study  and application required when a nonprescription (over-the-counter or  OTC) drug product has been marketed in the United States for a "material  time" and to a "material extent".


This allows the drug to be considered GRAS (generally recognized as safe)  under the  OTC monograph system, potentially avoiding the need for an extensive and expensive T&E study, or  a full New Drug  Application (NDA), or a duplicating a previous time and extent study.  


 While  some products marketed as "bioidentical" are available OTC, they source the constituent chemical manufacturer produced bio-compatible compositions  as used in the prescription formulations,  as B-HRT as a derivative of natural substances. They are therefore exempt from the regulation of the FDA's  product registration processes, which basically require the oversight by a physician, and therefore a prescription      


The following is  a more detailed explanation: 

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1. FDA Regulation and Compounding Pharmacies:   

  • The FDA regulates prescription drugs, including many hormone replacement therapies (HRT), to ensure safety and effectiveness. 
  • Compounding  pharmacies, which create custom B-HRT formulations, are not subject to  the same level of FDA oversight as commercially manufactured  medications. 
  • This  means that the quality, purity, and potency of compounded B-HRT products  may vary from batch to batch, and there's no guarantee of consistency  or reliability. 
  • The FDA has not approved any compounded BHRT drugs and cannot assure their safety or effectiveness. 

2. Over-the-Counter Options:   

  • Some products marketed as "natural" or "bioidentical" are available OTC, often as dietary supplements. 
  • These products typically contain phytoestrogens, which are plant-based compounds that can mimic estrogen in the body. 
  • Examples include soy products, flaxseed, and certain fruits and vegetables. 
  • While  generally considered safe for consumption in food, the effectiveness  and safety of phyto-estrogen supplements for menopause symptoms are not  definitively established. 

3. Why Prescription is Usually Required:   

  • Prescription B-HRT products are formulated to deliver specific doses of hormones that have been tested and approved by the FDA. 
  • They are often tailored to individual needs based on a doctor's assessment and prescription. 
  • This  ensures a higher degree of safety and efficacy compared to OTC  products, which may not be as well-regulated or standardized. 
  • Many women choose to seek prescription BHRT to address specific menopause symptoms and manage potential risks. 


What Are Bio-identical Hormones?

What Are Bio-identical Hormones?

Bio-identical hormones are hormones that  are structurally and chemically exact duplicates of the hormones  naturally produced by your body.

They are derived from plant sources such  as yams and soybeans and are designed to mimic the molecular structure  of hormones such as estrogen, progesterone, and testosterone. Generally  speaking, bio-identical hormones are safer and more effective than  synthetic hormones made by large-scale pharmaceutical labs.


But because they are “made to order,”  it’s important to note that not all bio-identical hormones are created  equal.


 While bio-identical hormones may be considered safer than  traditional HRT, the quality and purity of compounded bio-identical  hormones can vary depending on the compounding pharmacy.  That is why one must place a reliance on the reputation of the manufacturer by their FDA credentials as a manufacturer. 

Ask about Private Labeling our proprietary products for your company

Whatever your need or the size of your project, we commit to your satisfaction every step of the way.  Our job is to produce the best possible product at the most competitive price in order to make your business successful.  We truly commit to our client’s advancement and look to provide long term partnerships that provide sustainability, consistency and profitability.


SFM provides product research, development and manufacturing services in the health care and beauty products segment. We specialize in skin and personal care products, over the counter (OTC) products and nutraceutical supplements.


SFM has over 30 years of combined experience in the formulation and manufacture of nutraceutical supplements, health & beauty products and OTC medications.


Our highly qualified experts and experienced professionals are able to create advanced formulations using the highest quality natural ingredients that are safe, effective and based on the latest in cutting edge research and compounding science.


Our reliable specialty formulations ensure profitability and customer satisfaction, enabling you to compete in the business world with lower volumes and higher margins.


We take pride in providing the highest level of individualized customer care servicing customers worldwide including the United States, Canada, South America, European Union, Africa, Middle East and Asia.


Our facility in Phoenix is an FDA Registered, AZ Board of Pharmacy Approved Private Label Manufacturer.


Some of our proprietary formulations available for your choice of packaging, can be found here...

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